Our mission

René Jacquier, a chemical engineer, was responsible for major discoveries in the fields of light, matter and biosynthesis. Improving and normalising cell oxygenation to boost the vitality of living beings and their natural defences was his major preoccupation.

His work with major pharmaceutical groups in Brazil on antibiotics, hormones, enzymes, etc. enabled him to study an enormous diversity of molecules essential to human health.

In 1946, he perfected a method of oxygenation, without added oxygen, using molecules derived from pine resin, transformed into oxygen carriers. A forward-looking solution for living and breathing in an age of pollution.

On 22 June 1989, the newspaper Libération ran a special edition entitled "La Terre perd la boule" ("The Earth is losing its marbles"). In it, all the ecological disasters that have now been confirmed are described.

More specifically, it showed a mother giving her child "the oxygen feed", using a mask and a small bottle of gas. The scene takes place in Mexico City, at an altitude of 2,240 metres. The air there is highly polluted. This woman thought she was doing something good for her child, but she risked damaging the integrity of the alveoli in her lungs.

For Marie-Laure Delanef, the Bol d'air solution for providing oxygen simply and naturally to the organisms that need it was an obvious choice.

Holiste was created in November 1989.

In 2002, Europe 1 devoted two hours to René Jacquier. He captivated thousands of listeners. The switchboard was overwhelmed, and many users testified. Under this impetus, Holiste took a quantum leap forward, developing its technology and embarking on a new scientific approach, thanks to Professor Decristofaro and Professor Pietrobelli, who were impressed by this method of oxygenation without added oxygen.

In 2008, Béatrice Mercier, PhD in the biology of oxygenation, defended her doctoral thesis on the Bol d'Air at the University of Dijon. After 5 years of research, the oxygenating and protective action of the Bol d'air Jacquier method against free radicals was confirmed.

A multidisciplinary approach led to new observations and publications.

Pine resin contains the active ingredients of the Bol d'air Jacquier oxygenation method, Holiste's flagship product.

It is the essential raw material for the development and sustainability of its business.

To ensure the quality, traceability and quantity of its supplies, Holiste is taking an environmental approach and developing an innovative ecological harvesting method, which is likely to preserve the forest and the large coniferous trees, and protect the fauna as well as the health of the gemmeur.

BioGemme then offers co-products to industrialists committed to the ecological transition, to create new eco-sourced materials.

As part of its commitment to environmental health, Holiste is interested in the well-being of animals, the source of their balance and health. Holiste is making its first adaptation of the Bol d'Air for a large animal.

This product, the result of numerous observations, has been acclaimed by breeders, riding schools, horse care professionals... and by the horse itself, which loves it!

Holiste becomes ambassador for the Bourgogne-Franche-Comté region at the Made in France trade show. The health situation, far from dampening public and professional interest in Bol d'air, reinforced their awareness that the method offered a real solution to better overall health. This craze has led to further progress for the company.

Holiste continues to develop strong partnerships, in an open ecosystem where the synergy of skills is at the service of new ambitions. One of the company's major ambitions is the creation of a zero-waste environmental model. "We want to add value to the entire life cycle of our products!